Endocrine Abstracts

The sonic hedgehog (shh) pathway is known to be essential for pituitary development but little is known of its role in adult pituitary. Patched1, encoded by the Patched1 (Ptch1) gene, is a receptor for shh expressed in all cell types of the anterior pituitary. Adult onset hypogonadotropic hypogonadism has been reported in a genetically engineered mouse line with deletion of Ptch1 using S100a4 promoter driven CRE recombinase expression which is restri...